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KMID : 0363620070280020224
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 2 p.224 ~ p.240
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The Effects of Jiyu-tang against Gastric and Ileac Mucosal Ulcer Induced by Indomethacin in Mouse
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Kang A-Mi
Choi Eun-Young
Kim Hak-Jae
Han Yi-Soo
Lim Seong-Woo
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Abstract
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Objective : This study was carried out to investigate the effect of Jiyu-tang on gastric and ileac mucosal ulcer induced by indomethacin in mouse.
Methods : The normal group was that no inflammation elicited mouse. Control group is that water administered mouse after gastro-inflammation elicitation. Sample group is that Jiyu-tang administered mouse after gastro-inflammation elicitation.
Results : In the common morphology and histochemical change, control group were observed various injury by hemorrhagic erosion, while sample group was noticeably decreased than control group. In the immunohistochemical change, the distributions of COX-1 treated with Jiyu-tang noticeably increased than control group(p<0.05). The distributions of COX-2, MAC 387 and HSP-70, PCNA and TUNEL treated with Jiyu-tang noticeably decreased than control group(p<0.05).
Conclusion : According to the above results, it is supposed that Jiyu-tang is applicable to gastric and ileac mucosal ulcer.
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KEYWORD
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Jiyu-tang, Gastric Ulcer, Ileac Ulcer, COX-1, COX-2
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